It’s easy to spend most of the holidays (and beyond) with a glass of wine in hand, but could your favorite evening beverage be making you sick? A little buzz definitely isn’t worth the ongoing pain of an allergic reaction, but you might not even have ever noticed that wine routinely causes certain symptoms. For all but the most serious of wine allergies, symptoms can be mild and easily mistaken for seasonal allergies, a cold, or a hangover.

Although it’s possible for people to be allergic to alcohol in general, wine-specific allergies are more likely to be caused by sulfites, histamine, or other compounds in wine (that may be found in lower levels or not at all in other alcoholic beverages). Red wine tends to contain more of these sometimes-problematic components than white wine, because several originate in the grapes’ skin (and are therefore left out of white wine). Though the skins of grapes may be responsible for some of wine’s health benefits, they’re outweighed by the negatives of an actual allergic reaction. Here are some ways to tell:

1. You’re A Woman

Disappointingly, according to one study, women are twice as likely to have a wine allergy than men. Obviously, this isn’t enough information to diagnose anyone. But right off the bat you’re more likely than a guy to need to lay off the adult juice. Bummer.